CJC-1295 2mg

CJC-1295 is a synthetic analogue of GHRH (growth hormone releasing hormone) composed of 30 amino acids. It has demonstrated significant effectiveness in promoting the secretion of growth hormone and IGF-1 while maintaining the natural pulsatility of GH secretion.

 

CJC-1295 is frequently paired with Ipamorelin due to its improved specificity as a GHRH. This peptide also stimulates growth hormone secretion but does not trigger increased appetite or elevated levels of cortisol, acetylcholine, prolactin, or aldosterone, which are common with other peptides in this category. It is well-tolerated and works well in combination with Ipamorelin.

 

Gland Stimulated: Pituitary

 

Benefits of CJC-1295:

 

Enhanced secretion of growth hormone and IGF-1 levels without increasing prolactin

Boosted body weight and length via increased protein synthesis

Enhanced muscle development

Increased bone density

Boosted immune function

Enhanced cognition and memory

Improved collagen production

Facilitated fat loss

Promoted cellular repair and regeneration

 

CJC-1295 also aids in inducing slow wave deep sleep, which is crucial for optimal muscle growth, memory retention, and rejuvenation.

 

Two variations of CJC-1295:

 

GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release there stimulates a similar pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life refers to the duration needed to eliminate half of a substance from the bloodstream; a shorter half-life indicates faster removal from the body and a reduced effect).

 

The first 29 amino acids of GHRH constitute the active segment. This segment is available as a manufactured peptide known as Sermorelin. Sermorelin was modified further to extend its half-life to 30 minutes, and this is referred to as CJC-1295. Additionally, CJC-1295 was enhanced by incorporating DAC (Drug Affinity Complex), which attaches to a blood protein called albumin, extending its half-life to 8 days. This form is known as CJC-1295 + DAC. CJC-1295 can also be formulated in a non-DAC variant that mimics a more physiological GH spike each night.

 

The prolonged half-life due to DAC binding to albumin allows for injections to be needed only once or twice weekly. Nonetheless, the extended half-life and relatively stable blood levels provide a continuous trigger for GH release from the pituitary via the GHRH receptor, which is not physiological. This can diminish GH pulse amplitude, leading to a reduction in GH tissue stimulation.